A cholinergic checkpoint controls autoantibody selection via somatic hypermutation in lupus germinal...

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Systemic lupus erythematosus (SLE) pathogenesis involves the dysregulated production of mutated, high-affinity autoantibodies, a process primarily orchestrated within germinal centers (GCs). However, the precise regulatory mechanisms governing the GC-mediated generation of autoantibodies in SLE rema…

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